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KMID : 0895420000100020109
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Journal of Korean Society of Occupational and Enviromental Hygiene
2000 Volume.10 No. 2 p.109 ~ p.123
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Study on Inhalation toxicity of Halogen Compound Using Rats
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이종윤/Lee, Jong Yun
이성배/한정희/정용현/김현영/맹승희/임철홍/Lee, Sung bae/Han, Jung Hee/Chung, Yong Hyun/Kim, Hyeon Yeong/Maeng, Seung Hee/Lim, Cheol Hong
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Abstract
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Inhaled halogen compound was examined through micronucleus tests and toxicity tests using SD (Sprague-Dawley) rats with repeated dosages for six hours a day, five days a week, during four weeks.
In four-week repeated exposure, no specific sign caused by the CF₃I compound was observed on the clinical symptoms, body weight variation, feed consumption, and urinalysis data in the testing groups with reference to the control group. In hematological and biochemical blood tests of the testing groups, the significant, but in their normal ranges, value dependences of glucose, aspartate aminotransferase, alanine aminotransferase and etc., on the halogen carbohydride concentration was observed. In histo-pathological tests, no specific lesion or concentration dependent change due to the CF₃I compound dosage was observed m both sexes of the female and male in the tested animals.
But, micronucleus tests on marrow cells extracted from the tested animals which were repeatedly exposed in the CF₃I compound during four weeks, the frequencies of micronuclei were significantly increased dose-dependently compared to the control groups.
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